2,4-Difluoroaniline

CAS367-25-9

Nā waiwai kemika: mea ʻaila melemele keʻokeʻo.

Nā Hoʻohana: ʻO 2,4-Difluoroaniline kahi waena i ka synthesis organik. I nā lāʻau lapaʻau, hoʻohana ʻia ia i ka synthesis o ka difluorophenylsalicylic acid a me ka polyfluorodiphenyl acid. ʻO ka Difluorophenylsalicylic acid kahi lāʻau anti-inflammatory nonsteroidal carboxylic acid (NSAID), me ka inoa nonproprietary honua (INN) Diflunisal. ʻO kēia derivative hou o ka salicylic acid, ʻoiai ʻaʻohe o ka hui acetyl o aspirin, aia kahi hui difluorophenyl, e hopena ana i nā hopena ʻaoʻao antiplatelet liʻiliʻi, nā hopena gastrointestinal palupalu, a me ka lōʻihi o ka hana e mau ana he 8-12 mau hola. ʻO ia paha ka lāʻau salicylic acid hoʻohiki nui loa. He waena koʻikoʻi nō hoʻi ia i ka hana pesticide.

ʻO ke ʻano molekole C6H5F2N,

kaumaha molekala 129.11,

Helu EINECS 206-687-5

Kiko heheʻe -7.5 °C (lit.)

Ka paila ʻana 170 °C/753 mmHg (lit.)

Ka nui o ka paʻa 1.268 g/mL ma 25 °C (lit.)

ʻIke kuhikuhi refractive n20/D 1.506 (lit.)

Wahi lapalapa 145 °F

ʻAno Hana 1. ʻAno Hoʻemi 2,4-Difluoronitrobenzene: Hoʻohui ʻia ka pauka hao a me ka wai ammonium chloride i loko o kahi reactor hoʻemi, hoʻomehana ʻia i ka reflux, a laila hoʻohui ʻia ka 2,4-difluoronitrobenzene i kēlā me kēia kulu. Ma hope o ka pau ʻana o ka hoʻohui ʻana, reflux no 2 mau hola. Ma hope o ka pau ʻana o ka hopena, hoʻoheheʻe ʻia ka huahana i ka mahu, hoʻokaʻawale ʻia e Chemicalbook, a hoʻomaloʻo ʻia me ka calcium chloride e loaʻa ai kahi huahana kūpono me ka hua o 87%. 2. Loaʻa mai 1,2,4-trichlorobenzene ma o ka nitration, fluorination, a me ka dechlorination reductive; a i ʻole loaʻa mai m-phenylenediamine ma o ka diazotization, substitution, nitration, a me ka hoʻemi ʻana.

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